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Apart from its neuroprotective and neuromodulatory effects, 3-THP is also strongly associated with birth outcomes in humans and with the neurodevelopment of the newborn in an indirect manner, since pregnancy is characterized by an increase in the levels of P4 and 3-THP in the maternal plasma due to the placental synthesis (116, 117), which also impacts the behavioral and cognitive development of the newborn (118)

ProBDNF and mature BDNF as punishment and reward signals for synapse elimination at mouse neuromuscular junctions

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To investigate the effect of BDNF on hippocampal cognitive functions after global cerebral ischemia in rats, BDNF was administered continuously over 14 days via an osmotic mini-pump, intracerebroventricularly after four-vessel occlusion